Three-generation toxicity study of rats ingesting Brown HT in the diet
Identifieur interne : 001D05 ( Main/Exploration ); précédent : 001D04; suivant : 001D06Three-generation toxicity study of rats ingesting Brown HT in the diet
Auteurs : B. A. Mangham [Royaume-Uni] ; S. R. Moorhouse [Royaume-Uni] ; D. Grant [Royaume-Uni] ; P. G. Brantom [Royaume-Uni] ; I. F. Gaunt [Royaume-Uni]Source :
- Food and Chemical Toxicology [ 0278-6915 ] ; 1987.
English descriptors
- Teeft :
- Adult animals, Adverse effects, Autopsy, Body weight, Brown body, Brown body weight, Brown coloration, Caecal enlargement, Caecum, Caecum weights, Certain food additives, Coloration, Colouring, Colouring matter, Control group, Control groups, Corpora lutea, Cosmet, Daily intakes, Difference test, Dose level, Dose levels, Experimental design, Female deaths, Female deaths litters, Female group, Female rats, First mating, Foetal, Foetal weight, Foetus, Food additives, Food regulations, Free access, Full autopsy, Full examination, Gross autopsy, Highest dose, Histological examination, Joint expert committee, Kidney, Kidney weight, Kidney weights, Litter, Litter losses, Litter survival, Lymph, Lymph nodes, Major metabolite, Male rats, Mesenteric lymph nodes, Naphthionic acid, Neurological development, Next generation, Node, Organ weights, Positive observation, Positive response, Pregnant females, Random mote, Rat, Relative weights, Retarded ossification, Scientific committee, Second mating, Significant differences, Significant increase, Significant increases, Significant result, Skeletal abnormalities, Skeletal ossification, Slight evidence, Snedecor cochran, Statistical methods, Teratology, Test diets, Third sternebrae, Thyroid gland, Toxicity, Toxicity studies, Toxicity study, Toxicol, Treatment group, Uterine contents, Uterine horn, Viable litters, Water consumption, Water intakes, Weanling rats, Young rats.
Abstract
Abstract: Brown HT was fed to rats of both sexes over three generations at dietary concentrations designed to provide daily intakes of 0, 50, 250 and 500 mg Brown HT/kg body weight/day. During the study a number of females died or failed to nurse their litters. This was so severe following the first mating of F1 adults that the animals were remated to provide the next generation. None of these effects were related to treatment. Body weight and food and water intakes were not adversely affected by treatment. No effects of treatment were seen on reproductive performance or foetal and pup development, apart from slight evidence of a treatment-related retarded ossification of the third sternebrae. Organ weights at autopsy showed two changes, one of which was increased kidney weights which, although not present in every generation, seemed to be related to treatment. The other, increased caecum weights, occurred in adult high-dose females of early generations, but not in males or later generations of the study. Apart from brown coloration of tissues, macroscopic and microscopic examination revealed no treatment-related changes. It was concluded that the no-untoward-effect level in the present study was 250 mg Brown HT/kg/day.
Url:
DOI: 10.1016/0278-6915(87)90295-X
Affiliations:
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A." last="Mangham">B. A. Mangham</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey SM5 4DS</wicri:cityArea></affiliation></author><author><name sortKey="Moorhouse, S R" sort="Moorhouse, S R" uniqKey="Moorhouse S" first="S. R." last="Moorhouse">S. R. Moorhouse</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey SM5 4DS</wicri:cityArea></affiliation></author><author><name sortKey="Grant, D" sort="Grant, D" uniqKey="Grant D" first="D." last="Grant">D. 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Gaunt</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey SM5 4DS</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Food and Chemical Toxicology</title><title level="j" type="abbrev">FCT</title><idno type="ISSN">0278-6915</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987">1987</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="999">999</biblScope><biblScope unit="page" to="1007">1007</biblScope></imprint><idno type="ISSN">0278-6915</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0278-6915</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adult animals</term><term>Adverse effects</term><term>Autopsy</term><term>Body weight</term><term>Brown body</term><term>Brown body weight</term><term>Brown coloration</term><term>Caecal enlargement</term><term>Caecum</term><term>Caecum weights</term><term>Certain food additives</term><term>Coloration</term><term>Colouring</term><term>Colouring matter</term><term>Control group</term><term>Control groups</term><term>Corpora lutea</term><term>Cosmet</term><term>Daily intakes</term><term>Difference test</term><term>Dose level</term><term>Dose levels</term><term>Experimental design</term><term>Female deaths</term><term>Female deaths litters</term><term>Female group</term><term>Female rats</term><term>First mating</term><term>Foetal</term><term>Foetal weight</term><term>Foetus</term><term>Food additives</term><term>Food regulations</term><term>Free access</term><term>Full autopsy</term><term>Full examination</term><term>Gross autopsy</term><term>Highest dose</term><term>Histological examination</term><term>Joint expert committee</term><term>Kidney</term><term>Kidney weight</term><term>Kidney weights</term><term>Litter</term><term>Litter losses</term><term>Litter survival</term><term>Lymph</term><term>Lymph nodes</term><term>Major metabolite</term><term>Male rats</term><term>Mesenteric lymph nodes</term><term>Naphthionic acid</term><term>Neurological development</term><term>Next generation</term><term>Node</term><term>Organ weights</term><term>Positive observation</term><term>Positive response</term><term>Pregnant females</term><term>Random mote</term><term>Rat</term><term>Relative weights</term><term>Retarded ossification</term><term>Scientific committee</term><term>Second mating</term><term>Significant differences</term><term>Significant increase</term><term>Significant increases</term><term>Significant result</term><term>Skeletal abnormalities</term><term>Skeletal ossification</term><term>Slight evidence</term><term>Snedecor cochran</term><term>Statistical methods</term><term>Teratology</term><term>Test diets</term><term>Third sternebrae</term><term>Thyroid gland</term><term>Toxicity</term><term>Toxicity studies</term><term>Toxicity study</term><term>Toxicol</term><term>Treatment group</term><term>Uterine contents</term><term>Uterine horn</term><term>Viable litters</term><term>Water consumption</term><term>Water intakes</term><term>Weanling rats</term><term>Young rats</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Brown HT was fed to rats of both sexes over three generations at dietary concentrations designed to provide daily intakes of 0, 50, 250 and 500 mg Brown HT/kg body weight/day. During the study a number of females died or failed to nurse their litters. This was so severe following the first mating of F1 adults that the animals were remated to provide the next generation. None of these effects were related to treatment. Body weight and food and water intakes were not adversely affected by treatment. No effects of treatment were seen on reproductive performance or foetal and pup development, apart from slight evidence of a treatment-related retarded ossification of the third sternebrae. Organ weights at autopsy showed two changes, one of which was increased kidney weights which, although not present in every generation, seemed to be related to treatment. The other, increased caecum weights, occurred in adult high-dose females of early generations, but not in males or later generations of the study. Apart from brown coloration of tissues, macroscopic and microscopic examination revealed no treatment-related changes. It was concluded that the no-untoward-effect level in the present study was 250 mg Brown HT/kg/day.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mangham, B A" sort="Mangham, B A" uniqKey="Mangham B" first="B. A." last="Mangham">B. A. Mangham</name></region><name sortKey="Brantom, P G" sort="Brantom, P G" uniqKey="Brantom P" first="P. G." last="Brantom">P. G. Brantom</name><name sortKey="Gaunt, I F" sort="Gaunt, I F" uniqKey="Gaunt I" first="I. F." last="Gaunt">I. F. Gaunt</name><name sortKey="Grant, D" sort="Grant, D" uniqKey="Grant D" first="D." last="Grant">D. Grant</name><name sortKey="Moorhouse, S R" sort="Moorhouse, S R" uniqKey="Moorhouse S" first="S. R." last="Moorhouse">S. R. Moorhouse</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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